Recent progress in gene delivery using non-viral transfer complexes

The delivery of genetic material into cells is a field that is expanding ve ry rapidly. Non-viral delivery methods, especially ones that focus on the u se of chemical agents complexed with genetic material, are the focus of thi s mini-review. More-recent uses of known transfection agents such as poly(e thylenimine), poly(L-lysine), and various liposomes are discussed, and some novel approaches (both chemical and methodical) are reviewed as well. A ve ry brief look at how non-viral gene delivery research is being aimed at the clinic is also included. (C) 2001 Elsevier Science B.V. All rights reserve d.