Toxicity studies in mice of Commiphora molmol oleo-gum-resin

Acute (24 h) and chronic (90 days) oral toxicity studies on Commiphora molm ol (oleo-gum-resin) were carried out in mice. Dosages in acute study were 0 .5, 1.0 and 3 g/kg, while in chronic study dosage was 100 mg/kg per day. Al l external morphological, biochemical and haematological changes, in additi on to body and viral organ weights were recorded. There was no significant difference in mortality in acute or chronic treatment as compared to contro ls. At the end of the treatment, weight gain in the treated as well as cont rol group was significant. There was a significant increase in weight of te stes, caudae epididymides and seminal vesicles in C. molmol treated group. Biochemical studies revealed no differences in C. molmol treated animals, h owever, haematological studies revealed a significant increase in RBC and h aemoglobin levels as compared to the control group. C. molmol failed to sho w any spermatotoxic effects. (C) 2001 Elsevier Science Ireland Ltd. All rig hts reserved.