Asymmetric borane reduction of ketones promoted by menthopyrazole-ZnCl2 complex

Authors
Kashima, C Tsukamoto, Y Miwa, Y Higashide, K
Citation
C. Kashima et al., Asymmetric borane reduction of ketones promoted by menthopyrazole-ZnCl2 complex, J HETERO CH, 38(3), 2001, pp. 601-606
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
38
Issue
3
Year of publication
2001
Pages
601 - 606
Database
ISI
SICI code
0022-152X(200105/06)38:3<601:ABROKP>2.0.ZU;2-J
Abstract
The enantioselective reduction of ketones was accomplished by borane in the presence of pyrazole derivatives, particularly 2-methoxymethyl-3-phenyl-l- menthopyrazole (8). The catalysis of zinc chloride makes it possible to low er the reaction temperature below 0 degreesC, and to promote enantioselecti vity.