Ec. Cortes et al., Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines, J HETERO CH, 38(3), 2001, pp. 663-669
A series of twelve new 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and
p-substituted)phenyl]-7chloro-1,4-benzodiazepines, which have possible phar
macological properties has been obtained. The synthesis was carried out fol
lowing six steps. The structure of all products was corroborated by ir, H-1
nmr, C-13 nmr and ms. In addition for the compound 2-(o-chloroaminophenyl)
-3H-5-(o-fluorophenyl)-7-chloro-1,4-benzodiazepine 7, its structure was con
firmed by X-ray diffraction.