Retroperitoneal fibrosis is a rare disease characterized by the formation o
f dense plaque of fibrous tissue covering the retroperitoneal structures. T
his disease is commonly presented as ureteral obstruction, but the involvem
ent of duodenum is rare. We report a case of retroperitoneal fibrosis which
was complicated with duodenal stenosis and was successfully treated with c
orticosteroids. A 58-yr-old man, who had history of aorto-iliac bypass graf
t due to arteriosclerosis obliterans with infrarenal aortic occlusion was a
dmitted to the hospital with abdominal pain and a mass. Abdominal CT scan r
evealed the periaortic soft tissue mass encircling grafted aorta and stenos
is of duodenal third portion. Retroperitoneal fibrosis with duodenal stenos
is was diagnosed and prednisolone therapy was initiated. Follow-up CT scan
showed that the patient responded to prednisolone therapy with eased pain,
shrinking periaortic mass, and reduced duodenal stenosis.