Clinical importance of extended-spectrum beta-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains

Recently, an extended-spectrum beta -lactamase (PER-I) was found to be diss eminated among Acinetobacter spp, and Pseudomonas aeruginosa isolates in Tu rkey. A population-based cohort study was conducted to elucidate predictive mortality factors in patients with nosocomial infections caused by Acineto bacter spp. and P. aeruginosa, with particular reference to PER-1-type exte nded-spectrum beta -lactamase (ESBL) production. The study group comprised 16 and 21 non-survivors and 82 and 126 survivors in cohorts infected with A cinetobacter and E. aeruginosa, respectively. In the Acinetobacter-infected cohort, nosocomial pneumonia, hypotension and infection with a PER-positiv e isolate were independent predictors of mortality. In the P. aeruginosa-in fected cohort, impaired consciousness, a PER-positive isolate, male sex and (with a negative relative risk) urinary tract infection were independent p redictors of death. This study demonstrated the relationship of PER-1-type ESBL-producing Acinetobacter spp. and P. aeruginosa with poor clinical outc ome.