Two new cytotoxic and virucidal trisulfated triterpene glycosides from theantarctic sea cucumber Staurocucumis liouvillei

Authors
Maier, MS Roccatagliata, AJ Kuriss, A Chludil, H Seldes, AM Pujol, CA Damonte, EB
Citation
Ms. Maier et al., Two new cytotoxic and virucidal trisulfated triterpene glycosides from theantarctic sea cucumber Staurocucumis liouvillei, J NAT PROD, 64(6), 2001, pp. 732-736
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
732 - 736
Database
ISI
SICI code
0163-3864(200106)64:6<732:TNCAVT>2.0.ZU;2-E
Abstract
Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated ft om the Antarctic sea cucumber Staurocucumis liouville i. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A(1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from s ea cucumbers belonging to the family Cucumariidae. Both glycosides were fou nd to be virucidal against herpes simplex virus type 1 (HSV-1) at concentra tions below 10 mug/mL.