Chemical constituents from Lippia sidoides and cytotoxic activity

Authors
Costa, SMO Lemos, TLG Pessoa, ODL Pessoa, C Montenegro, RC Braz-Filho, R
Citation
Smo. Costa et al., Chemical constituents from Lippia sidoides and cytotoxic activity, J NAT PROD, 64(6), 2001, pp. 792-795
Citations number
15
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
792 - 795
Database
ISI
SICI code
0163-3864(200106)64:6<792:CCFLSA>2.0.ZU;2-X
Abstract
Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their struct ures were established by a combination of 1D and 2D NMR, IR, and EIMS spect ral data analysis. The cytotoxic properties of compounds 3-13 were evaluate d against HL60, SW1573, and CEM cell lines. Only tectol (6) and lippsidoqui none (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.