Increased endothelin-1 plasma levels in patients with multiple sclerosis

Objective: We tested the hypothesis that the plasma level of endothelin-1 ( ET-1) is increased in patients with multiple sclerosis (MS). The peptide ET -1 is one of the most potent known vasoconstrictors. An increased level of endothelin could explain some of the vascular symptoms of these patients. Materials and Methods: A specific radioimmunoassay was used to determine ET -1 plasma levels. Twenty patients with MS were compared to 20 age- and sex- pair-matched healthy subjects. Results: The plasma ET-1 levels were, on average, 224% higher in the patien ts with MS than in the controls (p < 0.005). The mean ET-1 levels (mean +/- standard deviation [SD]) were 3.5 +/- 0.83 pg/mL (min 2.13, max 5.37 pg/mL ) in patients with MS and 1.56 +/- 0.3 pg/mL (min 0.9, max 2.13 pg/mL) in h ealthy volunteers. Neither the different forms nor stages of MS had an infl uence on the results. The ET-1 level was also not correlated with the durat ion of the disease. Conclusions: The plasma ET-1 level is markedly and significantly increased in patients with MS. Neither the cause of such an increase nor the pathogen etic role is known.