THE OCCURRENCE OF ENDOMETRIAL ADENOCARCINOMA IN A PATIENT WITH BASAL-CELL NEVUS SYNDROME

Basal cell nevus syndrome is a rare multisystem disorder. Its genital implications in female patients is thought to be limited to ovarian fi broma. This article describes endometrial adenocarcinoma in associatio n with basal cell nevus syndrome in a 37-year-old Female with multiple basal cell carcinomas, mandibular and maxillary bone cysts, right ova rian fibroma, and scoliosis. Histopathologic examination of her endome trial biopsy, performed for irregular uterine bleeding, revealed endom etrial hyperplasia. Her bleeding failed to respond to progestin therap y, and a repeat endometrial biopsy revealed a well differentiated endo metrial adenocarcinoma. Health-care providers are encouraged to refer these patients to gynecologists. Regular gynecologic examination as we ll as appropriate evaluation of abnormal menstrual bleeding should be emphasized.