Spectrofluorometric determination of ibuprofen in pharmaceutical formulations

Authors
Damiani, PC Bearzotti, M Cabezon, MA
Citation
Pc. Damiani et al., Spectrofluorometric determination of ibuprofen in pharmaceutical formulations, J PHARM B, 25(3-4), 2001, pp. 679-683
Citations number
38
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
25
Issue
3-4
Year of publication
2001
Pages
679 - 683
Database
ISI
SICI code
0731-7085(200106)25:3-4<679:SDOIIP>2.0.ZU;2-9
Abstract
The spectrofluorometric determination of ibuprofen in pharmaceutical tablet s, creams and syrup is described. It involves excitation at 263 nm and emis sion at 288 nm. The linear range is 2-73 mg L-1. Other drugs or excipients present in the different formulations do not interfere, except in the case of chlorzoxazone containing tablets. Due to its strong absorbance in the sp ectral range the chlorzoxazone does interfere, so that in this case the pro posed method can't be applied. (C) 2001 Elsevier Science B.V. All rights re served.