Goal: We sought to describe the common demographic and comorbid conditions
that affect survival following nontraumatic amputation. Methods: Veterans A
dministration hospital discharge records for 1992 were linked with death re
cords. The most proximal level during the first hospitalization in 1992 was
used for analysis. Demographic information (age, race) and comorbid diagno
sis (cardiovascular, cerebrovascular, and renal disease) were used for Kapl
an-Meier curves to describe survival following amputation. Main Outcome Mea
sure: Death. Results: Mortality risk increased with advanced age, more prox
imal amputation level, and renal and cardiovascular disease, and decreased
for African Americans. No increased risk for persons: with diabetes was not
ed in the first year following amputation but the risk increased thereafter
A higher risk of mortality in the first year was noted for renal disease,
cardiovascular disease,;md proximal amputation level. Conclusion: Survival
following lower-limb amputation is impaired by advancing age, cardiovascula
r and renal disease, and proximal amputation level. Also, a small survival
advantage is seen for African Americans and those with diabetes.