Pathogenesis of influenza A (H5N1) virus infection in a primate model

Authors
Rimmelzwaan, GF Kuiken, T van Amerongen, G Bestebroer, TM Fouchier, RAM Osterhaus, ADME
Citation
Gf. Rimmelzwaan et al., Pathogenesis of influenza A (H5N1) virus infection in a primate model, J VIROLOGY, 75(14), 2001, pp. 6687-6691
Citations number
27
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
14
Year of publication
2001
Pages
6687 - 6691
Database
ISI
SICI code
0022-538X(200107)75:14<6687:POIA(V>2.0.ZU;2-U
Abstract
Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/H ong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fe ver associated with a necrotizing interstitial pneumonia. Reverse transcrip tion PCR, virus isolation, and immunohistochemistry showed that the respira tory tract is the major target of the virus.