Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity

Authors
Harandi, AM Svennerholm, B Holmgren, J Eriksson, K
Citation
Am. Harandi et al., Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity, J VIROLOGY, 75(14), 2001, pp. 6705-6709
Citations number
44
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
14
Year of publication
2001
Pages
6705 - 6709
Database
ISI
SICI code
0022-538X(200107)75:14<6705:I(AIAI>2.0.ZU;2-1
Abstract
Using a combination of gene-targeted mice and neutralizing antibodies, we s howed that interleukin-12 (IL-12) and IL-18 are important in the innate con trol of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a pro tective gamma interferon-mediated immune response.