A FACILE SOLUTION AND SOLID-PHASE SYNTHESIS OF PHOSPHOTYROSINE MIMETIC 4-[DIETHYLPHOSPHONO(DIFLUOROMETHYL)]-PHENYLALANINE (F(2)PMP(ETO)(2))DERIVATIVES

Authors
QABAR MN URBAN J KAHN M
Citation
Mn. Qabar et al., A FACILE SOLUTION AND SOLID-PHASE SYNTHESIS OF PHOSPHOTYROSINE MIMETIC 4-[DIETHYLPHOSPHONO(DIFLUOROMETHYL)]-PHENYLALANINE (F(2)PMP(ETO)(2))DERIVATIVES, Tetrahedron, 53(32), 1997, pp. 11171-11178
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
32
Year of publication
1997
Pages
11171 - 11178
Database
ISI
SICI code
0040-4020(1997)53:32<11171:AFSASS>2.0.ZU;2-K
Abstract
The F(2)Pmp derivatives were prepared in 80-90% yield from commerciall y available protected L-l-iodophenylalanine by esterification with dia zomethane followed by a CuCl-mediated coupling to (diethylphosphonyl) difluoromethylcadmium bromide. Moreover, treatment of L-4-iodoPhe-cont aining peptides under the same coupling conditions provided the F,Pmp- containing peptides in very good yields. (C) 1997 Elsevier Science Ltd .