C. Preibisch et A. Haase, Perfusion imaging using spin-labeling methods: Contrast-to-noise comparison in functional MRI applications, MAGN RES M, 46(1), 2001, pp. 172-182
Citations number
41
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
In this study the performance of FLASH imaging with selective inversion pre
paration for functional perfusion studies was investigated, In addition to
the absolute quantification of perfusion by measurement of the longitudinal
relaxation times with global (T-1glob) and selective (T-1set) inversion, t
he measurement of absolute (BASE) and relative (FAIR) perfusion increases b
y subtraction of appropriately weighted images was also considered, The sub
ject averages of absolute perfusion obtained by the quantitative method wer
e 70.7 +/- 4.0 ml/100g/min in gray matter, 10.2 +/- 3.4 ml/100g/min in whit
e matter, and 89.0 +/- 3.1 ml/100g/min in visual cortex. These values, as w
ell as the average increase of perfusion due to visual stimulation (44.4 +/
- 3.7 ml/100g/min), agree well with respective data reported by PET and oth
er MRI studies, However, for individual subjects the standard deviations ov
er single ROls inside the visual cortex lay around 100% which prevented the
detection of significant activation, BASE and FAIR, on the other hand, wer
e able to detect significant activation in single subjects. The measured av
erage perfusion increases were 51.7 +/- 6.6 ml/100g/min and 56.5 +/- 13.8%,
respectively, Magn Reson Med 46:172-182, 2001, (C) 2001 Wiley-Liss, Inc.