Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate

The public availability of numerous microbial genomes is enabling the analy sis of bacterial biology in great detail and with an unprecedented, organis m-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here se quences and functional annotations for 2.1-Mbp of pneumococcal DNA, coverin g more than 90% of the total estimated size of the genome. The sequenced st rain is a clinical isolate resistant to macrolides and tetracycline. It car ries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneu mococcal lineage that most often empresses a serotype 15 capsular polysacch aride. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all d escribed two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.