Efficient routes to omega-chloroalkyl bilirubins and C12-N22 bridged biliverdins

Authors
Tu, B Chen, QQ Yan, F Ma, JS Grubmayr, K Falk, H
Citation
B. Tu et al., Efficient routes to omega-chloroalkyl bilirubins and C12-N22 bridged biliverdins, MONATS CHEM, 132(6), 2001, pp. 693-705
Citations number
54
Categorie Soggetti
Chemistry
Journal title
MONATSHEFTE FUR CHEMIE
ISSN journal
00269247 → ACNP
Volume
132
Issue
6
Year of publication
2001
Pages
693 - 705
Database
ISI
SICI code
0026-9247(200106)132:6<693:ERTOBA>2.0.ZU;2-7
Abstract
omega -Chloroalkyl biliverdins, prepared in three steps from 8-unsubstitute d dipyrrinones in 70-80% overall yields, were reduced by sodium borohydride to provide the corresponding omega -chloroalkyl bilirubins in high yields. Upon treatment of the omega -cihloroalkyl biliverdins with sodium hydroxid e in ethanol, C12-N22 bridged biliverdins were obtained in high yields.