A short and efficient synthesis of novel N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-carboxamides

Several novel N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-ca rboxamides were prepared by acyl coupling of 2-aminobenzophenones with alph a-(benzotriazol-1-yl)-N-acylglycines followed by displacement of the benzot riazole ring with ammonia and cyclization of the resulting monoacyl aminals . In addition to high yields and shorter reaction sequences due to avoiding deprotection and acylation of the protected 3-amino-1,4-benzodiazepin-2-on e intermediates, the present approach did not involve the use of toxic and odoriferous materials as is the case with other methods.