Background: Exposure to a whiplash injury implies a risk for development of
chronic disability and handicap, with reported frequencies ranging from 0%
to 50% in follow-up studies. The exact risk for development of chronic whi
plash syndrome is not known. Objective: To prospectively determine the sens
itivity and specificity of five possible predictors for handicap following
a whiplash injury. Methods: In a 1-year prospective study of persons with a
cute whiplash injury (n = 141) and control subjects who had acute ankle dis
tortion (n = 40), pain intensity, number of nonpainful neurologic complaint
s, cervical mobility, workload during extension and flexion of the neck, an
d results of psychometric assessment were recorded. The consecutively sampl
ed injured persons were assessed with structured and semistructured questio
nnaires, and underwent neurologic examination after 1 week and 1, 3, 6, and
12 months. After 3 to 4 years, participants with whiplash injury were ques
tioned about legal issues. Results: After 1 year, 11 (7.8%) persons with wh
iplash injury had not returned to usual level of activity or work. The best
single estimator of handicap was the cervical range-of-motion test, which
had a sensitivity of 73% and a specificity of 91% (p < 0.01, Cox regression
analysis). Accuracy and specificity increased to 94% and 99% when combined
with pain intensity and other complaints. This increase was gained at the
expense of a reduced sensitivity. Initiation of lawsuit within first month
after injury did not influence recovery. Conclusion: The cervical range-of-
motion test has a high sensitivity in prediction of handicap after acute wh
iplash injury. The value of cervical range-of-motion test is further improv
ed by additional recording of symptoms and pain intensity.