SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice

Authors
Rogers, DC Peters, J Martin, JE Ball, S Nicholson, SJ Witherden, AS Hafezparast, M Latcham, J Robinson, TL Quilter, CA Fisher, EMC
Citation
Dc. Rogers et al., SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice, NEUROSCI L, 306(1-2), 2001, pp. 89-92
Citations number
5
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
306
Issue
1-2
Year of publication
2001
Pages
89 - 92
Database
ISI
SICI code
0304-3940(20010622)306:1-2<89:SAPFBA>2.0.ZU;2-1
Abstract
Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised ass essment of mouse phenotype and has been reported in a high throughput exper iment in which different mutants were ascertained at one age point using st age 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurologi cal dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis. (C) 2001 Elsevier Science I reland Ltd. All rights reserved.