[(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy

Citation
Js. Fowler et al., [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy, NUCL MED BI, 28(5), 2001, pp. 561-572
Citations number
70
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
09698051 → ACNP
Volume
28
Issue
5
Year of publication
2001
Pages
561 - 572
Database
ISI
SICI code
0969-8051(200107)28:5<561:[PSOCP>2.0.ZU;2-4
Abstract
Cocaine was initially labeled with carbon-11 in order to track the distribu tion and pharmacokinetics of this powerful stimulant and drug of abuse in t he human brain and body. It was soon discovered that [C-11]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that it is also a sensitive radiotracer for dopamine transport er (DAT) availability. Measures of DAT availability were facilitated by the development of a graphical analysis method (Logan Plot) for reversible sys tems which streamlined kinetic analysis. This expanded the applications of [C-11]cocaine to studies of DAT availability in the human brain and allowed the first comparative measures of the degree of DAT occupancy by cocaine a nd another stimulant drug methylphenidate. This article will summarize prec linical and clinical research with [C-11]cocaine. (C) 2001 Elsevier Science Inc. All rights reserved.