SPECTROFLUOROMETRIC ESTIMATION OF ASPIRIN AND DIPYRIDAMOLE IN PURE ADMIXTURES AND IN DOSAGE FORMS

Aspirin and dipyridamole in pure admixtures and in dosage forms have b een estimated by spectrofluorometry. Aspirin (2-12 meg ml(-1)) was est imated in 1% v/v glacial acetic acid in chloroform using 246 and 345 n m for excitation and emission respectvely. Dipyridamole (2-12 meg ml(- 1)) has been estimated in chloroform using 420 nm for excitation and 4 75 nm for emission. The non-interference of the excipients as well as the drugs in the estimation of each other, as evidenced by the results , indicate that this method may be used for the routine estimation of aspirin and dipyridamole in tablet preparations. (C) 1997 Elsevier Sci ence B.V.