OPTIMIZATION OF THE REVERSED-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF ATOVAQUONE, PROGUANIL AND RELATED SUBSTANCES

Authors
DEAGUIAR PF VANDERHEYDEN Y VANOOST Y COOMBER TJ MASSART DL
Citation
Pf. Deaguiar et al., OPTIMIZATION OF THE REVERSED-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF ATOVAQUONE, PROGUANIL AND RELATED SUBSTANCES, Journal of pharmaceutical and biomedical analysis, 15(11), 1997, pp. 1781-1787
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
15
Issue
11
Year of publication
1997
Pages
1781 - 1787
Database
ISI
SICI code
0731-7085(1997)15:11<1781:OOTRLS>2.0.ZU;2-E
Abstract
The optimisation of the separation of the antimalarial drugs, proguani l and atovaquone and six related compounds was obtained by two indepen dent optimisation steps; the optimisation of the mobile phase composit ion and the optimisation of the pH. This was done using window selecti on diagrams (WSD) and a mixture design. The optimal conditions allow t he identification of the six related compounds down to 0.1%. (C) 1997 Elsevier Science B.V.