Effect of the universal base 3-nitropyrrole on the selectivity of neighboring natural bases

Authors
Oliver, JS Parker, KA Suggs, JW
Citation
Js. Oliver et al., Effect of the universal base 3-nitropyrrole on the selectivity of neighboring natural bases, ORG LETT, 3(13), 2001, pp. 1977-1980
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
13
Year of publication
2001
Pages
1977 - 1980
Database
ISI
SICI code
1523-7060(20010628)3:13<1977:EOTUB3>2.0.ZU;2-Q
Abstract
[GRAPHICS] The effect of the universal base 3-nitropyrrole on the pairing selectivity of neighboring nucleosides has been determined for every combination of com plementary and neighboring nucleosides, In a subset of cases the discrimina tory ability of the neighboring nucleoside for its Watson-Crick complement is compromised. The results have implications for the hybridization of olig onucleotides that contain 3-nitropyrrole and suggest caution in the use of oligonucleotides that contain other universal bases.