Copper-catalyzed coupling of arylboronic acids and amines

Authors
Antilla, JC Buchwald, SL
Citation
Jc. Antilla et Sl. Buchwald, Copper-catalyzed coupling of arylboronic acids and amines, ORG LETT, 3(13), 2001, pp. 2077-2079
Citations number
25
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
13
Year of publication
2001
Pages
2077 - 2079
Database
ISI
SICI code
1523-7060(20010628)3:13<2077:CCOAAA>2.0.ZU;2-4
Abstract
[GRAPHICS] A general catalytic coupling of arylboronic acids and amines is reported. T his room-temperature coupling was realized through the use of catalytic cop per(II) acetate, 2,6-lutidine as base, and myristic acid as an additive. Fu nctionalized aniline substrates provided the diarylamine coupling products in good yield (58-91%), A variety of alkylamines were also successfully cou pled to give N-alkyl anilines in moderate yield (50-64%).