Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5+2] cycloaddition

[GRAPHICS] A concise asymmetric synthesis of the tricyclic core of cyathane diterpenes is described, based on a novel transition-metal-catalyzed intramolecular [ 5 + 2] cycloaddition of ynone-vinylcyclopropane 10 (assembled from commerci ally available (S)-(-)-limonene), which proceeds in 90% yield with > 95% se lectivity. This strategy provides efficient access (14 steps and 13% overal l yield) to potential analogues as well as precursors of nerve growth facto r (NGF)-inducing diterpenes.