Dihydroxynortropane alkaloids from calystegine-producing plants

Three dihydroxynortropanes, 2 alpha ,7 beta -dihydroxynortropane, 2 alpha , 3 beta -dihydroxynortropane, and 3 alpha ,7 beta -dihydroxynortropane, were isolated from calystegine-producing plants in the families Convolvulaceae and Solanaceae. 2 alpha ,7 beta -Dihydroxynortropane was isolated from six species in the Convolvulaceae whereas only Calystegia soldanella contained it and 2 alpha ,3 beta -dihydroxynortropane. Although neither of these were detectable in three species tested in the Solanaceae, 3 alpha ,7 beta -dih ydroxynortropane was, however, isolated from Duboisia leichhardtii. (C) 200 1 Elsevier Science Ltd. All rights reserved.