Bioactivity-directed fractionation of the CH2Cl2/MeOH (2:1, v/v) extract of
the roots of Petiveria alliacea, using mutant yeast strains of Saccharomyc
es cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum
led to the isolation of dipropyl disulphide (1), dibenzyl sulphide (2), dib
enzyl disulphide (3), dibenzyl trisulphide (4), dibenzyl tetrasulphide (5),
benzylhydroxymethyl sulphide (6) and di(benzyltrithio) methane (7). Of the
se, 5-7 are new compounds and this is the first report of the natural occur
rence of 2 and 3. (C) 2001 Elsevier Science Ltd. All rights reserved.