Antiprotozoal activity of Neurolaena lobata

Extracts, fractions and sesquiterpene lactones from Neurolaena lobata (L,) R, Br, (Asteraceae), a traditional medicinal plant from Guatemala, were tes ted in vitro against Leishmania spp, promastigotes, Trypanosoma cruzi trypo mastigotes and epimastigotes and Trichomonas vaginalis trophozoites, The et hanol extract inhibited the parasite growth of L, mexicana, T. cruzi and T, vaginalis significantly, The pure germacranolides 1 and a mixture of 2 and 3, isolated from the ethonal extract, were highly active against L, mexica na and T, cruzi, Copyright (C) 2001 John Wiley & Sons, Ltd.