Various bioactive substances in kiwifruit extracts were fractionated by org
anic solvent extractions, followed by silica gel and ODS chromatographies,
Both cytotoxic activity and multi-drug resistance reversal activity were fo
und in the less polar fractions. Cytotoxic activity was not always parallel
the radical intensity. Antibacterial activity was distributed into various
fractions and all fractions were inactive against Candida albicans and H,
pylori, Only 70% methanol extracts showed anti-human immunodeficiency virus
activity, and produced a broad ESR signal under alkaline conditions, in a
fashion similar to lignin, These fractions also effectively scavenged O-2(-
) produced by the xanthine-xanthine oxidase reaction, suggesting a bimodal
(pro-oxidant and antioxidant) action. These data suggest a medicinal effica
cy of kiwifruit peel extracts. Copyright (C) 2001 John Wiley & Sons, Ltd.