A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites

Long-lasting forms of activity-dependent synaptic plasticity involve molecu lar modifications that require gene expression. Here, we describe a cellula r mechanism that mediates the targeting newly synthesized gene transcripts to individual synapses where they are locally translated. The features of t his mechanism have been revealed through studies of the intracellular trans port and synaptic targeting of the mRNA for a recently identified immediate early gene called activity-regulated cytoskeleton-associated protein Are. Are is strongly induced by patterns of synaptic activity that also induce l ong-term potentiation, and Are mRNA is then rapidly delivered into dendrite s after episodes of neuronal activation. The newly synthesized Are mRNA loc alizes selectively at synapses that recently have been activated, and the e ncoded protein is assembled into the synaptic junctional complex. The dynam ics of trafficking of Are mRNA reveal key features of the mechanism through which synaptic activity can both induce gene expression and target particu lar mRNA transcripts to the active synapses.