METABOLIC AND NEUROLOGICAL PATTERNS IN CHRONIC CEREBRAL INFARCTION - A SINGLE-VOXEL H-1-MR SPECTROSCOPY STUDY

The details of brain metabolism in chronic cerebral infarcts have not been clarified. Using proton MR spectroscopy (H-1-MRS) at 1.5 T, we me asured biochemical changes in 16 patients with large infarcts involvin g the motor cortex in the chronic phase (median 293.9 days) and relate d the findings to clinical data. Localised spectra were obtained using point-resolved spectroscopy, with an echo time of 270 ms. Regions of interest were placed on the frontal lobe. including the precentral gyr us and central sulcus, Motor function was assessed by the manual muscl e power test at the time of the H-1-MRS study. Only three patients wit h severe paresis had no signal in the lesions and a lactate signal was obtained in 13 cases, N-acetyl aspartate (NAA) was observed in 3 case s with recanalisation of an occluded vessel. Motor function correlated strongly with the NAA/choline-containing compounds (Cho) ratio (P < 0 .01) and lactate/Cho ratio (P < 0.01). We found various metabolic patt erns, reflecting residual neurological function.