Laser Doppler imaging is a noninvasive method yielding a spatial perfusion
map. With use of a near-infrared laser, elevated perfusion associated with
the metacarpophalangeal joints was detectable in patients with active rheum
atoid arthritis. Findings at laser Doppler imaging correlated with pain sco
res and synovitis detected at ultrasonography, whereas the power Doppler si
gn (red pixels inside the active green box) did not. Laser Doppler imaging
has the potential to help assess soft-tissue inflammation.