Synthesis of modified peptides with C-terminal alpha-amino aldehydes

Various synthetic approaches to modified peptides with the C-terminal aldeh yde group, capable of inhibiting a number of proteolytic enzymes belonging to the classes of thiol, serine, and aspartyl proteases, are considered. Bo th chemical methods, including solid phase peptide synthesis now widely use d, and biocatalytic synthetic methods for obtaining these substances are di scussed in detail.