Arachidonoylcholine and N,N-dimethylaminoethyl arachidonate, new cholinergic compounds

Authors
Bezuglov, VV Zinchenko, GN Nikitina, LA Buznikov, GA
Citation
Vv. Bezuglov et al., Arachidonoylcholine and N,N-dimethylaminoethyl arachidonate, new cholinergic compounds, RUS J BIOOR, 27(3), 2001, pp. 200-203
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
ISSN journal
10681620 → ACNP
Volume
27
Issue
3
Year of publication
2001
Pages
200 - 203
Database
ISI
SICI code
1068-1620(200105/06)27:3<200:AANANC>2.0.ZU;2-3
Abstract
Choline and N,N-dimethylaminoethyl esters of arachidonic and some other fat ty acids were synthesized. Experiments on the embryos and larvae of sea urc hins, sensitive to cholinergic compounds, showed that arachidonoylcholine e xhibited cholinomimetic activity similar to that of nicotine while N,N-dime thylaminoethyl arachidonate acted as acetylcholine antagonist. The correspo nding esters of docosahexaenoic acid were found to manifest similar biologi cal properties.