Combination therapy has proved useful in infectious, rheumatologic, and onc
ologic diseases. The role of combination therapy in sarcoidosis is less def
ined. A stepwise approach to therapy in sarcoidosis treatment includes mult
iple agents, such as topical and systemic corticosteroids, The introduction
of cytotoxic agents has led to the combination of these drugs with lowered
doses of corticosteroids. Recently, the combination of cytotoxic and immun
e modifiers has been used for some cases of refractory sarcoidosis, The rat
ionale use of combination therapy may enhance efficacy with reduced toxicit
y.