Combination therapy for sarcoidosis

Combination therapy has proved useful in infectious, rheumatologic, and onc ologic diseases. The role of combination therapy in sarcoidosis is less def ined. A stepwise approach to therapy in sarcoidosis treatment includes mult iple agents, such as topical and systemic corticosteroids, The introduction of cytotoxic agents has led to the combination of these drugs with lowered doses of corticosteroids. Recently, the combination of cytotoxic and immun e modifiers has been used for some cases of refractory sarcoidosis, The rat ionale use of combination therapy may enhance efficacy with reduced toxicit y.