Antibacterial susceptibility of intestinal lactobacilli of healthy children

We investigated the antibacterial susceptibility of intestinal lactobacilli of Estonian and Swedish children aged 1-2 y. Silty isolates (10 species) o f lactobacilli (29 Estonian and 31 Swedish strains) were tested against amp icillin, cefuroxime, cefoxitin, gentamicin, ciprofloxacin, tetracycline, va ncomycin, metronidazole and crythromycin. We observed that intestinal lactu bacilli do not display uniform susceptibility to antibiotics. None of the t ested lactobacilli was resistant to ampicillin, gentamicin and erythromycin , Single strains were resistant to cefuroxime and tetracycline, about half of the strains to cefoxitin and ciprofloxacin and 73% of the strains to van comycin. All studied strains were resistant to metronidazole. Most of the s trains investigated were resistant to two or three antibiotics: out of nine . Some differences in susceptibility were noted between strains belonging t o different fermentation types. No differences in susceptibility were found between Estonian and Swedish isolates. Metronidazole, cefoxitin, vancomyci n and ciprofloxacin seem to be safer for gastrointestinal lactoflora than o ther tested antibiotics in both countries.