Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections

Authors
White, DJ Habib, AR Vanthuyne, A Langford, S Symonds, M
Citation
Dj. White et al., Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections, SEX TRANS I, 77(3), 2001, pp. 212-213
Citations number
11
Categorie Soggetti
Clinical Immunolgy & Infectious Disease","da verificare
Journal title
SEXUALLY TRANSMITTED INFECTIONS
ISSN journal
13684973 → ACNP
Volume
77
Issue
3
Year of publication
2001
Pages
212 - 213
Database
ISI
SICI code
1368-4973(200106)77:3<212:CTFAAB>2.0.ZU;2-S
Abstract
Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to loca l and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) f ormulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily for 14 days with significant improvement, both clini cally and microbiologically.