The focus of health and mortality research is changing from individual-leve
l frameworks and analyses of disease causation to multilevel frameworks and
analyses that incorporate both individual and environmental or contextual
explanations. This research explores the meaning of neighborhood-the contex
tual-level variable used most often in health and mortality research-and di
scusses how neighborhood effects are related to health and mortality outcom
es. A conceptual model that proposes the pathways through which neighborhoo
d effects operate to influence health and mortality differentials is develo
ped. Neighborhoods have a social as well as a spatial dimension, and geogra
phically smaller neighborhoods often provide a more accurate measurement of
neighborhood effects. Neighborhoods affect health and mortality outcomes p
rimarily in an indirect fashion through proximate determinants such as smok
ing, diet, exercise, stress, and access to health insurance and medical pro
viders.