Enantioselective addition of diethylzinc to aldehydes catalyzed by fluorous beta-aminoalcohols

Authors
Nakamura, Y Takeuchi, S Okumura, K Ohgo, Y
Citation
Y. Nakamura et al., Enantioselective addition of diethylzinc to aldehydes catalyzed by fluorous beta-aminoalcohols, TETRAHEDRON, 57(26), 2001, pp. 5565-5571
Citations number
54
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
26
Year of publication
2001
Pages
5565 - 5571
Database
ISI
SICI code
0040-4020(20010625)57:26<5565:EAODTA>2.0.ZU;2-9
Abstract
A fluorous aminoalcohol prepared from ephedrine has been used as a catalyst for the enantioselective addition of diethylzinc to aldehydes to afford th e corresponding alcohols in up to 84% ee. The fluorous amino alcohol was ea sily recovered by a simple filtration through a fluorous reverse phase sili ca gel and was reusable without purification. (C) 2001 Elsevier Science Ltd . AU rights reserved.