A short synthesis of 5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-propanoic acid methyl ester

Authors
Henry, GE Jacobs, H
Citation
Ge. Henry et H. Jacobs, A short synthesis of 5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-propanoic acid methyl ester, TETRAHEDRON, 57(25), 2001, pp. 5335-5338
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
25
Year of publication
2001
Pages
5335 - 5338
Database
ISI
SICI code
0040-4020(20010618)57:25<5335:ASSO5A>2.0.ZU;2-Q
Abstract
5-Methoxy-2,2-dimethyl-2H-1-benzopyran-6-propanoic acid methyl ester was pr epared in five steps and approximately 20% overall yield from 2,4-dihydroxy benzaldehyde. The two key reactions are the chromenylation between the unch elated hydroxyl group and C-3 of the resbenzaldehyde and the demethoxycarbo nylation-alkylation of dimethyl malonate with a quaternary ammonium iodide. (C) 2001 Elsevier Science Ltd. All rights reserved.