Synthesis of (4R*,5R*)-4-acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid: new inhibitors of influenza virus sialidases

Authors
Kerrigan, SA Smith, PW Stoodley, RJ
Citation
Sa. Kerrigan et al., Synthesis of (4R*,5R*)-4-acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid: new inhibitors of influenza virus sialidases, TETRAHEDR L, 42(28), 2001, pp. 4709-4712
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
28
Year of publication
2001
Pages
4709 - 4712
Database
ISI
SICI code
0040-4039(20010709)42:28<4709:SO(>2.0.ZU;2-Z
Abstract
(4R*,SR*)-3-Acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R *)-3-acetylamino-3-diethylcarbamoyleyelohex -1-ene-2-carboxylic acid have been synthesised using a Diels-Alder tactic; both compounds are selective inhibitors of influenza A sialidase, the latter compound being pa rticularly potent. (C) 2001 Elsevier Science Ltd. All rights reserved.