Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates

Authors
Betancort, JM Sakthivel, K Thayumanavan, R Barbas, CF
Citation
Jm. Betancort et al., Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates, TETRAHEDR L, 42(27), 2001, pp. 4441-4444
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
27
Year of publication
2001
Pages
4441 - 4444
Database
ISI
SICI code
0040-4039(20010702)42:27<4441:CEDMAO>2.0.ZU;2-C
Abstract
Enantioselective direct Michael additions of ketones using (S)-1-(2-pyrrold inylmethyl)-pyrrolidine as a catalyst are described. Michael adducts with u p to 91% e.e. were obtained by the reaction of alkylidene malonates with si mple unactivated ketones under mild reaction conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.