Thermodynamic studies on the effects of cisplatin or its analog complexes on actin polymerization

The effects of cisplatin or its analog complexes on actin polymerization ha ve been. studied by the microcalorimetric and viscosity methods at the temp erature of 310.15 K. The thermodynamic parameters and the power-time curves of actin polymerization in the presence of cisplatin or its analog complex es (cis-DBDP, cis-DIDP, cis-DADP) are measured. The results show that there are different interaction mechanisms between actin and cisplatin or its an alog complexes. The relative viscosity of actin polymer decreases in the pr esence of cisplatin or its analogs, and also shows Pt concentration depende nce. It indicates that these compounds affect actin polymerization. It has been discussed from the experimental results that the presence of cisplatin or its analog complexes cause different polymerization mechanism of actin. (C) 2001 Published by Elsevier Science B.V.