Thyroid stimulating hormone downregulates vascular endothelial growth factor expression in FRTL-5 cells

Authors
Miyagi, E Katoh, R Li, X Lu, S Suzuki, K Maeda, S Shibuya, M Kawaoi, A
Citation
E. Miyagi et al., Thyroid stimulating hormone downregulates vascular endothelial growth factor expression in FRTL-5 cells, THYROID, 11(6), 2001, pp. 539-543
Citations number
34
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
THYROID
ISSN journal
10507256 → ACNP
Volume
11
Issue
6
Year of publication
2001
Pages
539 - 543
Database
ISI
SICI code
1050-7256(200106)11:6<539:TSHDVE>2.0.ZU;2-D
Abstract
We studied the regulation of the expression of vascular endothelial growth factor (VEGF) by TSH in monolayer cultures of rat thyroid FRTL-5 cell lines . The VEGF mRNA synthesis was significantly inhibited by TSH as well as dil outyryl cyclic adenosine monophosphate (cAMP) in a dose-dependent manner in FRTL-5 cells. This observation is contrary to previously published results using the thyroid follicular culture system. Our results suggest that the direct effect of TSH/cAMP is to inhibit the VEGF synthesis in monolayer cel ls.