C. Schwarz et al., The contribution of adhesion molecule expression in donor kidney biopsies to early allograft dysfunction, TRANSPLANT, 71(11), 2001, pp. 1666-1670
Background. Renal allograft rejection is associated with the expression of
adhesion molecules on vascular endothelial and tubular epithelial cells.
Methods. To assess whether the number of cell adhesion molecules expressed
in donor kidneys can predict early rejection or delayed graft function, kid
ney biopsies from 20 living and 53 cadaveric kidney donors were obtained be
fore engraftment into the recipients and the expression of the cell adhesio
n molecules intercellular adhesion molecule 1 (ICAM-1), vascular cell adhes
ion molecule 1 (VCAM-1), and endothelial leukocyte adhesion molecule (E-sel
ectin) were determined by immunohistochemistry.
Results. All biopsies from living donors showed significantly lower express
ion of ICAM-1 and VCAM-1 compared to biopsies from cadaveric donors. There
was no difference in the expression of adhesion molecules on tubular cells
between transplants with primary function compared to allografts with early
rejection in living donated kidneys (ICAM-1: 2 +/-8 vs. 3 +/-8%; VCAM-1: 9
+/-7 vs. 1 +/-1%), as well as in cadaveric kidneys (ICAM-1: 38 +/- 29 vs.
39 +/- 38%; VCAM-1: 55 +/- 27 vs. 48 +/- 29%). The expression of ICAM-1 mol
ecules on tubular cells was determined to be a predictor for the occurrence
of delayed graft function in cadaveric kidneys (ICAM-1: 65 +/- 24* vs. 38
+/- 29% delayed graft versus primary graft function). No delayed graft func
tion occurred in recipients of living donated kidneys.
Conclusions. These data suggest that adhesion molecule expression in donor
biopsies is not a predictor for early allograft rejection, but can be used
as a marker for the development of postischemic acute renal allograft failu
re.