Nuclear-receptor interactions on DNA-response elements

Nuclear receptors regulate transcription by binding to DNA-response element s using their conserved DNA-binding domains, These response elements contai n conserved hexameric sequences that can be arranged in various bipartite c onfigurations, including inverted and direct repeats. A series of structura l studies on receptor-DNA binding complexes illustrate the strategies used by receptors to recognize the symmetry of their binding site as well as its sequence. These structures also indicate how cooperation between receptors enhances their joint affinity and selectivity for correctly configured sit es.