The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

Authors
Adrain, C Martin, SJ
Citation
C. Adrain et Sj. Martin, The mitochondrial apoptosome: a killer unleashed by the cytochrome seas, TRENDS BIOC, 26(6), 2001, pp. 390-397
Citations number
50
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
6
Year of publication
2001
Pages
390 - 397
Database
ISI
SICI code
0968-0004(200106)26:6<390:TMAAKU>2.0.ZU;2-L
Abstract
The caspase family of cysteine proteases have emerged as central regulators of apoptosis. Diverse cellular stresses trigger caspase activation by prom oting release of mitochondrial components, including cytochrome c, into the cytoplasm,ln turn, cytochrome c promotes the assembly of a caspase-activat ing complex termed the apoptosome. In this article, the apoptosome and its role in life and death decisions of cells are discussed.