Ultrasound fibrin clot destruction in vitro in the presence of fibrinolytic agent

Ultrasound fibrin clot destruction was investigated in vitro using electron microscopy and by monitoring the changes in the light transmission of clot debris suspension. It has been established that in the course of a combine d action of ultrasound and fibrinolytic agent at high ultrasound intensitie s and short sonification periods, fibrin clot is disrupted mainly due to so nomechanical treatment, while fermentative lysis takes place in parallel an d at a significantly lower rate. However, the streptokinase action prevails after ultrasound switching off and results in the prevention of clot debri s conglomeration. (C) 2001 Elsevier Science B.V. All rights reserved.